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Professor of Food Science and Human Nutrition Dept of Food Science
and Human Nutrition
Area of Interest We have been interested in the effects of dietary changes upon the development of prostate cancer. We are currently looking at the impact of tomato, broccoli and their components upon delay of cancer development in the rat model. Lycopene, the red pigment of tomato, is of particular interest due to its antioxidant properties. We have noted that both dietary restriction (20%) and castration independly enhance the levels of lycopene in some tissues. Diet restriction or consumption of freeze-dried whole tomato or lycopene increase longevity of rats who were induced with prostate cancer with a chemical carcinogen. Publications Boileau, T.W.M., S.K.
Clinton & J.W. Erdman, Jr. 2000. Tissue lycopene concentrations and
isomer patterns are affected by androgen status and dietary lycopene concentrations
in male F344 rats. J. Nutr. (130:1613-1618). Boileau, T., S. Clinton,
Z. Liao, M. Monaca, S. Donovan & J. Erdman Jr 2001. Lycopene, tomato
powder and dietary restriction influence survival of rats with prostate
cancer induced by NMU and testosterone. J Nutr. 131: 191S. Boileau, T.W-M., S.K.
Clinton and J.W.Erdman, Jr. 2001. Testoterone and diet restriction modulate
hepatic lycopene isomer concentrations in male F344 Rats. J Nutr. 131:1746-1752.
Liao, Z., T.W-M. Boileau,
S.K Clinton and J.W. Erdman Jr. 2002. Angiogenesis is synchronized with
cell proliferation in prostate cancer induced by N-methyl-N-nitrolsourea
and testosterone in Wistar-Unilever rats. Manuscript in preparation. Liao, Z., T.W-M. Boileau, S.K Clinton and J.W. Erdman Jr. 2002. Loss of androgen receptor expression as prostate cancer progresses in Wistar-Unilever rats treated with N-methyl-N-nitrosourea and testosterone. Manuscript in preparation. Keywords Nutrition, Cancer, Androgen, Carotenoids, Diet |
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2001 University of Illinois @ Urbana-Champaign
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John
W. Erdman, Ph.D.